Emactuzumab

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Emactuzumab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1448221-67-7

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

Emactuzumab (RG 7155) 是一种特异性单克隆抗体，可抑制集落刺激因子 1 受体 (CSF1R) 的激活。Emactuzumab 对 CSF-1R 具有高亲和力，Ki 值为 0.2 nM，可阻断 CSF-1R 二聚化。Emactuzumab 可用于多种疾病的研究，如弥漫型腱鞘巨细胞瘤（dt-GCT）。

Cas No.

1448221-67-7

别名

RG 7155; RO 5509554

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

IC50: 0.2 nM (CSF-1R)^[2]

Emactuzumab(RG 7155) is a specificmonoclonal antibodythat inhibits colonystimulating factor 1 receptor(CSF1R)activation. Emactuzumab has high affinity for CSF-1R withK_ivalue of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT)^[1]^[2].

Emactuzumab (RG 7155) binds to human and cynomolgus CSF-1R with high affinity (K_d= 0.2 nM) to blocks CSF-1R dimerization^[2].
RG7155 (0-10 μg/mL, 7 days) potently inhibited the viability of CSF-1-differentiated macrophages with an IC₅₀of 0.3 nM by inducing cell death^[2].
RG7155 (30 μg/mL, 6 days) induces cell death of in vitro-differentiated human M2-like macrophages^[2].

Cell Viability Assay^[2]

Cell Line:	CSF-1 and/or GM-CSF Macrophages
Concentration:	0-10 μg/mL
Incubation Time:	7 days
Result:	Resulted cell death of CSF-1-differentiated macrophages.

Emactuzumab(RG 7155) (i.v.; 0.1、1、10、30 and 100 mg/kg; once) increases CSF-1 concentration in nonhuman primates' peripheral blood^[2].
RG7155 (i.v.; 0, 30, and 100 mg/kg; once weekly; for 2 weeks) depletes CSF-1R⁺CD163⁺macrophages in vivo^[2].

Animal Model:	cynomolgus monkeysMacaca fascicularis^[2]
Dosage:	0.1, 1, 10, 30 and 100 mg/kg (male cynomolgus monkeys) 0, 30, and 100 mg/kg (male and female cynomolgus)
Administration:	i.v., once (male cynomolgus monkeys) i.v., once weekly, for 2 weeks(male and female cynomolgus)
Result:	Increased CSF-1 concentration in serum. Efficiently reduced CSF-1R and CD68⁺163⁺macrophages in the liver (Kupffer cells) and colon of cynomologus monkeys.