Atibuclimab 是一种针对 CD14 的嵌合单克隆抗体，由小鼠可变区和人类 IgG4 Fc 区组成。Atibuclimab 可用于肌萎缩侧索硬化症的研究。Atibuclimab 可减轻 LPS 诱导的症状，并强烈抑制 LPS 诱导的促炎细胞因子释放，同时仅延迟抗炎细胞因子可溶性 TNF 受体 I 型和 IL-1 受体拮抗剂的释放。
| Cas No. | 2417175-94-9 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Atibuclimab, is a chimeric monoclonal antibody directed againstCD14and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis[1]. Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist[2]. |
