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H-Asp-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
H-Asp-OH图片
CAS NO:56-84-8
包装与价格：
包装价格(元)
10mM (in 1mL Water)询价
1g询价

H-Asp-OH
Cas No.56-84-8
别名L-天冬氨酸
化学名(2S)-2-aminobutanedioic acid
Canonical SMILESC(C(C(=O)O)N)C(=O)O
分子式C4H7NO4
分子量133.1
溶解度Soluble to 100 mM in 1eq. NaOH
储存条件Store at -20° C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].

References:
[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.
[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

 
 
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