化学性质
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 271.08 |
| Cas No. | 129318-43-0 |
| Formula | C4H12NNaO7P2 |
| Synonyms | Fosamax |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O with gentle warming |
| Chemical Name | sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate |
| Canonical SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
资料参考
Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.