ZED-1227 是一种特异性的、口服的转谷氨酰胺酶 2 (TG2) 抑制剂，能阻塞炎症诱导的 TG2 表达和激活，有作为治疗乳糜泻药物的前景。
| Cas No. | 1542132-88-6 |
| Canonical SMILES | O=C(OC)/C=C/CC[C@H](NC(C1=CN=CN1C)=O)C(NC2=CC=CN(CC(NCC(CC)CC)=O)C2=O)=O |
| 分子式 | C26H36N6O6 |
| 分子量 | 528.6 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ZED-1227 is a specific and oral transglutaminase 2 (TG2) inhibitor, which can block inflammation-induced TG2 expression and activity. ZED-1227 is a promising agent for the treatment of celiac disease (CeD)[1].
TG2[1] [1]. Manu Encalada, et al. The Oral Transglutaminase 2 (TG2) Inhibitor Zed1227 Blocks TG2 Activity in a Mouse Model of Intestinal Inflammation. Gastroenterology. 154(6):S-490. |
