Aspirin(Acetylsalicylic acid)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

50-78-2

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
1g	询价
5g	询价

化学性质

Storage	Store at -20°C
M.Wt	180.16
Cas No.	50-78-2
Formula	C₉H₈O₄
Synonyms	2-Acetoxybenzoic acid, Acylpyrin, Ecotrin, Acenterine, Polopiryna, Acetosal
Solubility	insoluble in H2O; ≥104.2 mg/mL in EtOH with ultrasonic; ≥8.55 mg/mL in DMSO
Chemical Name	2-acetyloxybenzoic acid
Canonical SMILES	CC(=O)OC1=CC=CC=C1C(=O)O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

阿司匹林（乙酰水杨酸）是一种有效的环氧化酶（COX）抑制剂，具有广谱的药理活性，包括抗炎和镇痛。多个研究积累了关于服用阿司匹林与降低癌症风险关系的充足证据，包括前列腺癌、乳腺癌、大肠癌、子宫内膜癌和卵巢癌。阿司匹林可充当组蛋白去乙酰化酶的抑制剂，上调细胞周期停滞蛋白p21，抑制携带COX-1的卵巢癌细胞。阿司匹林也能够在人类脐静脉内皮细胞和新生大鼠心肌细胞中抑制COX-2表达，从而分别导致PG生成减少和ERK与NF-KB下调。

参考文献：
Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013;4(8):671-678.
Duan Y, Chen F, Zhang A, Zhu B, Sun J, Xie Q, Chen Z. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Rep. 2013. pii: 2320. [Epub ahead of print]

试验操作

Cell experiment:[1]
Cell lines	Porcine alveolar macrophages
Reaction Conditions	3 mM aspirin for 30 min pretreatment
Applications	Aspirin inhibited lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity.
Animal experiment:[2]
Animal models	Male albino Charles River rats weighing between 200 and 250 g
Dosage form	5, 25, 50, 100 and 150 mg/kg Administered orally
Applications	Aspirin, administered orally at 5, 25, 50 and 100 mg/kg, exhibited antipyretic activity at all doses. The ED50 values calculated from these data ranged from 10.3 to 21.1 mg/kg. In addition, statistically significant antipyresis was demonstrated 15 min after an oral dose of 150 mg/kg of aspirin, with the maximum effect occurred at 120 min.
Note	The technical data provided above is for reference only.
	References: 1. Duan Y, Chen F, Zhang A, et al. Aspirin inhibits lipopolysaccharide-induced COX-2 expression and PGE2 production in porcine alveolar macrophages by modulating protein kinase C and protein tyrosine phosphatase activity. BMB Reports, 2014, 47(1): 45-50. 2. Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicology and Applied Pharmacology, 1972, 22(4): 672-675.