Sodium Oxamate

立即咨询

Sodium Oxamate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

565-73-1

包装与价格：

包装	价格(元)
5g	询价
10g	询价
25g	询价
50g	询价

化学性质

Storage	Store at -20°C
M.Wt	111.03
Cas No.	565-73-1
Formula	C₂H₂NNaO₃
Solubility	insoluble in EtOH; insoluble in DMSO; ≥11.1 mg/mL in H2O
Chemical Name	sodium 2-amino-2-oxoacetate
Canonical SMILES	[O-]C(C(N)=O)=O.[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Sodium oxamate is a competitive LDHA(actate dehydrogenase A) inhibitor, sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors[1,2].

References：

[1]. Anna Z K, De S M M L, Antonio S, et al. Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells. PLOS ONE, 2015, 10(3): e0119857.

[2]. Cui J, Shi M, Xie D, et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clinical Cancer Research, 2014, 20(10): 2595-2606.