Cyclic AMP

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Cyclic AMP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60-92-4

包装与价格：

包装	价格(元)
500mg	询价
1g	询价
5g	询价

化学性质

Storage	Store at -20°C
M.Wt	329.21
Cas No.	60-92-4
Formula	C₁₀H₁₂N₅O₆P
Synonyms	Adenosine 3-5-cyclic monophosphate
Solubility	insoluble in DMSO; insoluble in EtOH; ≥16.45 mg/mL in H2O
Chemical Name	(4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
Canonical SMILES	O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@@]4([H])[C@@]1([H])OP(OC4)(O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Cyclic adenosine 3’, 5’-monophosphate (cAMP) was the first second messenger to be identified, with the IC50 of LPA- or EGF-stimulated ERK1 was 0.1-0.2 Mm [1].

Ras is a common target for growth factors including epidermal growth factor (EGF) and lysophosphatidic acid (LPA), which activate the Raf-MEK-ERK pathway. Raf is likely to be a link between Ras and ERK cascade, of which Raf-1activates MEK in vitro.

Quiescent Rat1 cells were incubated with 1 Mm dibutyryl cAMP for 10 min before stimulation with LPA or EGF, ERK activation was completely inhibited by protein immunoblots. The ability of the phorbol ester PMA to activate MAP kinase was also inhibited by dibutyryl cAMP [1].

Reference:

[1] Cook S J, McCormick F. Inhibition by cAMP of Ras-Dependent Activation of Raf [J]. Science. 1993, 262(5136):1069-1072.