化学性质
| Storage | Store at -20°C |
| M.Wt | 554.5 |
| Cas No. | 52152-93-9 |
| Formula | C22H19N4O8S2·Na |
| Solubility | ≥22.75 mg/mL in DMSO with gentle warming; insoluble in EtOH; ≥49.3 mg/mL in H2O |
| Chemical Name | 4-(aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-pyridinium inner salt, monosodium salt |
| Canonical SMILES | O=C(N[C@@H]1C(N2[C@]1([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C2C([O-])=O)=O)[C@H](S([O-])(=O)=O)C4=CC=CC=C4.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. Cefsulodin shows little activity against other species of Acinetobacter spp., Pseudomonas, or members of the Enterobacteriaceae [1]. Cefsulodin is a β-lactam antibiotic that involved in lysing actively-growing E. coli by specifically binding to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation [2].
Cefsulodin was active against P. aeruginos. Cefsulodin was active against penicillinase-producing strains of S. aureus. The MICs of cefsulodin for Pseudomonas aeruginosa and its mutants Pseudomonas aeruginosa PAO4089 were 0·78 and 12· mg/l [3]. Cefsulodin was active in minimum inhibitory concentrations (MICs) of 0.5 to 64 μg/ml. Cefsulodin was active against P. diminuta, P. maltophilia, P. paucimobilis, and P. pseudoalcaligenes with MICs of 1-32 μg/ml. Cefsulodin was not hydrolyzed by the β-lactamase induced in P. aeruginosa by growth in the presence of benzylpenicillin and was a poor substrate for β-lactamases from Enterobacter cloacae and Proteus morganii [4].
References:
[1] Barry A L, Jones R N, Thornsberry C. Cefsulodin: antibacterial activity and tentative interpretive zone standards for the disk susceptibility test[J]. Antimicrobial agents and chemotherapy, 1981, 20(4): 525-529.
[2] Jacoby G H, Young K D. Cell cycle-independent lysis of Escherichia coli by cefsulodin, an inhibitor of penicillin-binding proteins 1a and 1b[J]. Journal of bacteriology, 1991, 173(1): 1-5.
[3] Bryan L E, Kwan S, Godfrey A J. Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin[J]. Antimicrobial agents and chemotherapy, 1984, 25(3): 382-384.
[4] King A, Shannon K, Phillips I. In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamases[J]. Antimicrobial agents and chemotherapy, 1980, 17(2): 165-169.
