Bufuralol(hydrochloride)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

60398-91-6

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	297.8
Cas No.	60398-91-6
Formula	C₁₆H₂₃NO₂·HCl
Synonyms	Ro 3-4787
Solubility	≤15mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical Name	α-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol, monohydrochloride
Canonical SMILES	CCC1=C(OC(C(O)CNC(C)(C)C)=C2)C2=CC=C1.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Bufuralol is a non-specific β-adrenergic blocker.

Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. Beta adrenergic agonists are a class of sympathomimetic agents that act upon the beta adrenoceptors.

In vitro: Bufuralol was identified as a non-cardioselective β-adrenoceptor antagonist which possessed partial agonist activity at the β-adrenoceptor. Bufuralol also showed membrane-stabilizing properties [1].

In vivo: Previous pharmacological studies in several species of animals showed that bufuralol exhibited non-selective β-adrenoceptor blocking properties similar to those of propranolol with comparable potency. Such effects were exerted on the β-adrenoceptor stimulant actions of injected amines and of sympathetic nerve stimulation. However, unlike propranolol, bufuralol possessed some instrinsic sympathomimetic activity as demonstrated by tachycardia in reserpinized rats [2].

Clinical trial: Clinical observations were made in eight subjects who exercised before and after the oral administration of placebo, bufuralol and propranolol. Results showed that the exercise heart rate remained constant after placebo. Bufuralol at 7.5 mg and propranolol at 40 mg could reduce exercise heart rate but bufuralol at 15, 30, 60 and 120 mg and propranolol at 160 mg were still active at 24 h. The lowest exercise heart rate occurred at 2 h after treatments. Bufuralol at 60 and 120 mg could produce similar reduction in exercise tachycardia as propranolol at 40 mg but less than propranolol at 160 mg [2].

References:
[1] Fothergill GA, Francis RJ, Hamilton TC, Osbond JM, Parkes MW. Bufuralol, a new beta-adrenoceptor blocking agent. Experientia. 1975 Nov 15;31(11):1322-3.
[2] Pringle, T. H.,Francis, R.J.,East, P.B., et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br.J.Clin.Pharmac. 22, 527-534 (1986).