25(S)-27-hydroxy Cholesterol

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CAS NO:

56845-83-1

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	402.7
Cas No.	56845-83-1
Formula	C₂₇H₄₆O₂
Synonyms	(25S)-26-hydroxy cholesterol
Solubility	≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide
Chemical Name	(25S)-cholest-5-ene-3β,26-diol
Canonical SMILES	O[C@@H]1CC2=CC[C@]3([H])[C@@](CC[C@]4([C@@]3([H])CC[C@]4([H])[C@@H](CCC[C@H](C)CO)C)C)([H])[C@](C)2CC1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

25(S)-27 hydroxy Cholesterol is a stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol. 27-hydroxy Cholesterol is a sterol 27-hydroxylase-mediated cholesterol hydroxylation product involved in activating LXRα and LXRβ and potently suppressing cholesterol biosynthesis [1,2].

Liver X receptors (LXRs) belong to the nuclear receptor superfamily member. LXRs are ligand-activated transcription factors containing two LXR isoforms termed as α and β. LXRs play central roles in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types. Activation of LXRs induces the expression of the genes involved in cholesterol absorption, transport, efflux, and excretion. LXRs are potential targets for a variety of diseases, such as hypertriglyceridemia [3]. LXRs have also been involved in modulating immune and inflammatory responses in macrophages [3].

25(S)-27 hydroxy Cholesterol was the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol. 27-hydroxy Cholesterol activated LXRα and LXRβ with the EC50 values of 85 and 71 nM, respectively [1,2].

References:
[1] Fu, X. ,Menke, J.G.,Chen, Y., et al. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. The Journal of Biological Chemisty 276(42), 38378-38387 (2001).
[2] Javitt, N. B. 25R,26-Hydroxycholesterol revisited: Synthesis, metabolism, and biologic roles. Journal of Lipid Research 43, 665-670 (2002).
[3] Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling[J]. The Journal of clinical investigation, 2006, 116(3): 607-614.