Indomethacin heptyl ester

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CAS NO:

282728-47-6

包装与价格：

包装	价格(元)
5mg (solution)	询价
10mg (solution)	询价
50mg (solution)	询价

化学性质

Physical Appearance	A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice.
Storage	Store at -20°C
M.Wt	456
Cas No.	282728-47-6
Formula	C₂₆H₃₀ClNO₄
Solubility	≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
Chemical Name	1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 1-heptyl ester
Canonical SMILES	ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(OCCCCCCC)=O)=C2C)=O)C=C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Indomethacin heptyl ester is a potent and selective COX-2 inhibitor with IC50 value of 0.04 μM [1].

The key step in thromboxane and prostaglandin biosynthesis involves the conversion of arachidonic acid to prostaglandin H2 (PGH2), a reaction catalyzed by the cyclooxygenase (COX) and peroxidase activities of prostaglandin endoperoxide synthase or cyclooxygenase. COX is composed of COX-1 and COX-2. COX-2 plays important role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system [1].

Indomethacin is a potent COX-1 and COX-2 inhibitor with IC50 value of 0.05 μM and 0.75 μM, and is also a nonsteroidal antiinflammatory drug. Indomethacin is a substituted indole acetic acid and many of the structurally diverse indomethacin esters and amides show enhanced selectivity for the COX-2 isoform. Indomethacin heptyl ester was more potent and selective COX-2 inhibitor with IC50 value of 0.04 μM and >66 μM for human recombinant COX-2 and COX-1, respectively [1].

Reference:
[1]. Kalgutkar AS, Marnett AB, Crews BC, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.