Sodium molybdate

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Sodium molybdate

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CAS NO:

7631-95-0

包装与价格：

包装	价格(元)
5g	询价
10g	询价

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	205.94
Cas No.	7631-95-0
Formula	MoNa₂O₄
Solubility	insoluble in EtOH; insoluble in DMSO; ≥20.6 mg/mL in H2O
Chemical Name	sodium molybdate
Canonical SMILES	[O-][Mo](=O)([O-])=O.[Na+].[Na+]
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Sodium molybdate is an acid phosphatase inhibitor. The osteoclastic acid phosphatase isoenzyme, secreted by osteoclasts, is a member of a widely-distributed class of iron-containing proteins with acid phosphatase activity. Elevated plasma isoenzyme levels are associated with increased bone turnover in metabolic disease. By inhibiting this class of acid phosphatases, sodium molybdate is capable of abolishing bone resorption. In addition, sodium molybdate has been shown to stabilize the nonactivated glucocorticoid-receptor complex.

References:

1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71.

2. Denis M, Wikstrom AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.

试验操作

Cell experiment:[1]
Cell lines	Rat osteoclasts
Reaction Conditions	1 ~ 100 μM sodium molybdate
Applications	Addition of the phosphatase inhibitor sodium molybdate to the bone-osteoclast cultures at a concentration of 100 μM abolished bone resorption and reduced tartrate-resistant acid phosphatase activity by about 40%.
Note	The technical data provided above is for reference only.
	References: 1. Zaidi M, Moonga B, Moss DW, et al. Inhibition of osteoclastic acid phosphatase abolishes bone resorption. Biochemical and Biophysical Research Communications, 1989, 159(1): 68-71. 2. Denis M, Wikstrom AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. Journal of Biological Chemistry, 1987, 262(24): 11803-11806.