化学性质
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 301.3 |
| Cas No. | 244616-85-1 |
| Formula | C18H11N3O2 |
| Solubility | ≤2.5mg/ml in DMSO;2.5mg/ml in dimethyl formamide |
| Chemical Name | 2-(3-quinolinylcarbonyl)-4(3H)-quinazolinone |
| Canonical SMILES | O=C1NC(C(C2=CC(C=CC=C3)=C3N=C2)=O)=NC4=CC=CC=C41 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
Luotonin F is an alkaloid found in the aerial parts of the Peganum nigellastrum Bunge, a plant which has been long used in traditional Chinese medicine for the treatment of rheumatism, abscesses, and various other inflammatory conditions [1].
Due to their biological and pharmaceutical activities, many synthetic methods have been developed for the synthesis of luotonins. An efficient one-pot synthetic protocol has been proposed for the synthesis of luntonin F from easily available starting materials. Through the rational logical design, multifundamental reactions were assembled in one-pot, such as iodination, Kornblum oxidation, and annulations [2]. The developed approach could efficiently synthesize luntonin F and various analogues. Luotonin F showed promising cytotoxicity against leukemia P-388 cells with an IC50 value of 2.3 μg/ml by stabilizing the DNA topoisomerase I-DNA complex [1].
References:
[1] Liang J L, Cha H C, Jahng Y. Recent advances in the studies on luotonins[J]. Molecules, 2011, 16(6): 4861-4883.
[2] Zhu Y, Fei Z, Liu M, et al. Direct one-pot synthesis of Luotonin F and analogues via rational logical design[J]. Organic letters, 2012, 15(2): 378-381.
