Citrinin

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Citrinin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

518-75-2

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	250.3
Cas No.	518-75-2
Formula	C₁₃H₁₄O₅
Synonyms	NSC 186
Solubility	≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name	(3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
Canonical SMILES	O=C1C(C)=C2[C@@H](C)[C@H](C)OC=C2C(O)=C1C(O)=O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Citrinin is a mycotoxin inducing apoptosis and blocking tubulin polymerization and mitotic spindle assembly.

Citrinin is a mycotoxin originally isolated from P. citrinum that is also produced by a variety of other fungi that are found as contaminants in human foodstuffs and animal feeds.

In vitro: Previous study found that exposure of HEK293 cells to citrinin led to an arrest of cell cycle G2/M in a concentration-dependent increase. Citrinin treatment could also elevate the expression levels of p53 and p21 proteins, yet attenuate the signals of phosphorylated cell division cycle 2. Moreover, treating HEK293 with citrinin could increase both the value of mitotic index and the population of cells, indicating that arrest of citrinin -induced cell cycle occurred mainly during the mitotic phase [1].

In vivo: Previous study showed that citrinin acted as a nephrotoxin in all tested animal species, but its acute toxicity varied in different species. The 50% lethal dose for ducks is 57 mg/kg; for chickens it is 95 mg/kg; and for rabbits it is 134 mg/kg. In murine kidneys, citrinin could also synergistically act with ochratoxin A to depress RNA synthesis [2].

Clinical trial: Up to now, there is no clinical data reported.

References:
[1] Chang CH, Yu FY, Wu TS, Wang LT, Liu BH. Mycotoxin citrinin induced cell cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule formation in human cells. Toxicol Sci. 2011 Jan;119(1):84-92.
[2] J. W. Bennett and M. Klich. Mycotoxins. Clin.Microbiol.Rev. 16(3), 497-516 (2003).