SW203668

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SW203668

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1673556-40-5

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	389.5
Cas No.	1673556-40-5
Formula	C₂₂H₁₉N₃O₂S
Solubility	≤20mg/ml in DMSO
Chemical Name	4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide
Canonical SMILES	COC1=CC=C2C(SC(NC(C3=CC=C(C(N)C4=CC=CC=C4)C=C3)=O)=N2)=C1
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

IC50: 0.022 μM for H2122 cells

SW203668 is a stearoyl CoA desaturase inhibitor.

The enzyme of stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids such as palmitoleic acid and oleic acid, which are two most abundant monounsaturated fatty acids in human membranes, plasma lipids as well as adipose tissue. Though the endogenous synthesis of fatty acids in humans is not significant in most circumstances, it is increasingly becoming evident that SCD plays key structural and metabolic roles.

In vitro: By the screening, the optimized benzothiazole SW203668 was found to be selectively toxic to various cell lines (IC50 = 0.022-0.116 μM). Moreover, the ectopic expression of CYP4F11 in H1155, an SW203668-insensitive cell line, led to its sensitization to toxicity by SW203668 and therefore these results confirmed that CYP4F11 could also activate SW203668 [1].

In vivo: A PK analysis of SW203668 revealed that the plasma levels exceeded 0.3 μM for the first 6 h and a half-life of 8 h after an intraperitoneal injection at 25 mg/kg. Immunodeficient mice bear-ing 200 mm3 tumors derived either from H2122 cells (sensitive) or H1155 cells (insensitive) was intraperitoneally treated with 25 mg/kg of SW203668 twice a day for 10–15 d. Results showed that after administration of SW203668 a substantially reduced rate of growth in H2122-derived tumors was observed. While the H1155-derived tumors were unaffected, suggesting that the selectivity and cytotoxicity of SW203668 were maintained in vivo [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Theodoropoulos PC et al. Discovery of tumor-specific irreversible inhibitors of
stearoyl CoA desaturase. Nat Chem Biol. 2016 Apr;12(4):218-25.