描述
| Gene ID: | 12367 | Accession #: | Q8BNT4 |
| Alternate Names: | Mouse Procaspase-3, Procaspase-3, procaspases, caspase-3 proenzyme, caspase-3 proform. |
| Source: | Escherichia Coli. | M.Wt: | 32.0 kDa |
| Appearance: | Lyophilized powder | Storage: | Store at -70℃ |
| Formulation: | Lyophilized powder |
| Solubility: | Reconstitute to 1 unit per μl in PBS containing 15% glycerol. |
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. |
资料参考
Caspase-3 (also know as CPP32, Yama and apopain) belongs to the caspase family of cysteine proteases. Caspase-3 exists in cells as an inactive proenzyme with a molecular mass of 32 kDa. This inactive proenzyme hydrolysis and generates the 17 kD and 12 kD subunits. The two subunits assembled as a tetramer to form the active caspase. Cascades of caspase activation have been shown to be crucial signal-transducing events in apoptosis. Activation of procaspase-3 stands at a point of convergence for the two major types of apoptosis signaling pathways-those linked to cell surface death receptors and mitochondrial release of cytochrome c. The recombinant Procaspase-3 is expression in E. coli. Active recombinant caspase-8 can activate the purified protein.
