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4'-Ethynyl-2'-deoxyadenosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4'-Ethynyl-2'-deoxyadenosine图片
CAS NO:306305-07-7

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA)，是一种核苷逆转录酶 (RT) 抑制剂， 是一种抗病毒药物，对耐药HIV变异型具有较强的抑制作用，在MT-4细胞中，EC50 值为 98 nM。
Cas No.306305-07-7
Canonical SMILESOC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
分子式C12H13N5O3
分子量275.26
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity[1]. EC50: 98 nM (MT-4 cells)[1].

[1]. Ohrui H, et al. 4'-C-substituted-2'-deoxynucleosides: a family of antiretroviral agents which are potent against drug-resistant HIV variants. Curr Drug Targets Infect Disord. 2001 May;1(1):1-10.

 
 
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