| CAS NO: | 108341-18-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 询价 |
| 500mg | 询价 |
| 1g | 询价 |
| 5g | 询价 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 337.28 |
| Cas No. | 108341-18-0 |
| Formula | C8H11NO3·C4H6O6·H2O |
| Solubility | insoluble in EtOH; ≥11.35 mg/mL in DMSO; ≥51 mg/mL in H2O |
| Chemical Name | 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate |
| Canonical SMILES | C1=CC(=C(C=C1C(CN)O)O)O.C(C(C(=O)O)O)(C(=O)O)O.O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Noradrenaline bitartrate monohydrate is an agonist of adrenergic receptors, with Ki values of 330, 56 and 740 nM for α1, α2 and β1 adrenoceptors, respectively [1].
Noradrenaline is a neurotransmitter distributed in both the peripheral and central nervous systems. In the autonomic nervous system, noradrenaline acting at α1-receptors causes constriction of cutaneous blood vessels. In the central nervous system, noradrenaline found primarily in the locus coeruleus in the brainstem, plays important roles in a variety of physiological activities, such as sleep/wake cycles, attention, orientation, mood and memory [2].
In femoral strips isolated from the untreated dogs, noradrenaline bitartrate monohydrate (5 × 10-9 ~ 10-4 M) induced dose-dependent contractions which were inhibited completely by 10-8 M phenoxybcnzamine administered 40 min previously. In the femoral strips isolated from the ephedrine-treated dogs, contractile responses to noradrenaline bitartrate monohydrate were potentiated at low concentrations (5 × 10-9 ~ 10-7 M) but inhibited at high concentrations (5 × 10-7 ~ 10-4 M) [3].
References:
[1]. Ramos B P, Arnsten A F. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacology & Therapeutics, 2007, 113(3): 523-536.
[2]. Bylund D B, Bylund K C. Norepinephrine. Encyclopedia of the Neurological Sciences (Second Edition), 2014, 3: 638–640.
[3]. Furukawa T, Morishita H. Modifications of responses to adrenergic drugs in arterial strip by treatment in vivo with ephedrine and reserpine. The Japanese Journal of Pharmacology, 1975, 25(4): 441-451.
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