Toll-Like Receptor 7 Ligand II (CL-087) 是一种有效的口服活性 TLR7 激动剂。
| Cas No. | 226907-52-4 |
| 别名 | 6-氨基-7,9-二氢-2-(2-甲氧基乙氧基)-9-(苯甲基)-8H-嘌呤-8-酮,CL-087 |
| Canonical SMILES | COCCOC1=NC(N)=C2C(N(CC3=CC=CC=C3)C(N2)=O)=N1 |
| 分子式 | C15H17N5O3 |
| 分子量 | 315.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells. It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 µM. At 10 µM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon. It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod . |
