Sograzepide (Netazepide)(Netazepide; YF 476; YM-220) 是一种极有效、高选择性和口服活性的 Gastrin/CCK-B 拮抗剂，IC50 值为 0.1 nM，对 Gastrin/CCK-A 活性有抑制作用，IC50 为 502纳米。
| Cas No. | 155488-25-8 |
| 别名 | Netazepide; YF 476; YM-220 |
| Canonical SMILES | O=C(NC1=CC=CC(NC)=C1)N[C@H]2C(N(CC(C(C)(C)C)=O)C3=CC=CC=C3C(C4=NC=CC=C4)=N2)=O |
| 分子式 | C28H30N6O3 |
| 分子量 | 498.58 |
| 溶解度 | DMSO : ≥ 100 mg/mL (200.57 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sograzepide (Netazepide;YF476) is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist. [1]. Boyce M, et al. Effect of netazepide, a gastrin/CCK2 receptor antagonist, on gastric acid secretion and rabeprazole-induced hypergastrinaemia in healthy subjects. Br J Clin Pharmacol. 2015 May;79(5):744-55. |
