化学性质
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 205.3 |
| Cas No. | 143360-00-3 |
| Formula | C13H19NO |
| Synonyms | SMIP 004;SMIP-004 |
| Solubility | insoluble in H2O; ≥20.5 mg/mL in DMSO; ≥53.6 mg/mL in EtOH with ultrasonic |
| Chemical Name | N-(4-butyl-2-methylphenyl)acetamide |
| Canonical SMILES | CCCCC1=CC(=C(C=C1)NC(=O)C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
IC50 Value: 1.09 uM (MTT assay in LNCaP-S14 cells) [1]
SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide) is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. Unlike SMIP001, SMIP004 was found to downregulate SKP2 and to stabilize p27, although neither SMIP is a proteasome inhibitor.
in vitro: Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2].
in vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2].
Clinical trial: N/A
