UCLA GP130 2 是一种有效的、脑渗透性和口服活性的 GP130 受体激动剂。
| Cas No. | 339303-87-6 |
| Canonical SMILES | FC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
| 分子式 | C15H11FN2S |
| 分子量 | 270.32 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | gp130 agonist. Protects against NMDA-induced toxicity in primary hippocampal neurons in vitro. Increases STAT3 phosphorylation in SH-SY5Y cells. Brain penetrant. Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID:29161500 |
