NB-598

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NB-598

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

131060-14-5

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
50mg	询价
200mg	询价

化学性质

Physical Appearance	A brown oil
Storage	Store at -20°C
M.Wt	449.67
Cas No.	131060-14-5
Formula	C₂₇H₃₁NOS₂
Synonyms	NB 598;NB598
Solubility	insoluble in H2O; ≥49.3 mg/mL in EtOH with gentle warming; ≥54 mg/mL in DMSO with gentle warming
Chemical Name	(E)-N-(3-([3,3'-bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine
Canonical SMILES	CCN(CC1=CC(OCC2=CC(C3=CSC=C3)=CS2)=CC=C1)C/C=C/C#CC(C)(C)C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibited by NB-598.

试验操作

Cell experiment:[1]
Cell lines	MIN6 cells, as well as mouse and human pancreatic islets
Reaction Conditions	10 μM NB-598 for 48 h incubation
Applications	Cholesterol reduction of 36 ~ 52% was observed in MIN6 cells, mouse and human pancreatic islets after a 48-h incubation with 10 μM NB-598. A similar reduction in cholesterol was observed in the subcellular compartments of MIN6 cells. In addition, inhibition of cholesterol biosynthesis by NB-598 impaired insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.
Note	The technical data provided above is for reference only.
	References: 1. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology, 2008, 149(10): 5136-5145.