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Bio-AMS TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bio-AMS TFA图片

Bio-AMS (TFA) 是一种有效的细菌生物素蛋白连接酶 (biotin protein ligase) 抑制剂。Bio-AMS (TFA) 可选择性地抑制结核分枝杆菌 (Mtb),并抑制脂肪酸和脂类生物合成。
生物活性

Bio-AMS (TFA) is a potentbacterialbiotin protein ligaseinhibitor. Bio-AMS (TFA) possesses selective activity againstMycobacterium tuberculosis(Mtb) and arrests fatty acid and lipid biosynthesis[1].

IC50& Target

Biotin protein ligase[1]

体外研究
(In Vitro)

Bio-AMS possesses excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM and is not affected by changes to the primary carbon source[1].
Bio-AMS (2.5, 5 and 10 μM; 24 h) inhibits growth of Mtb in a concentration-dependent manner inMtb-infected mouse macrophages; shows no signs of mitochondrial toxicity[2].

分子量

685.65

性状

Solid

Formula

C22H30F3N9O9S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month
 
 
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