Tomeglovir

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Tomeglovir

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CAS NO:

233254-24-5

托美洛韦
BAY 38-4766

Tomeglovir 是一种抗CMV剂，能够抑制病毒 DNA 多联体的进程，对 HCMV 和 MCMV 的IC₅₀值分别为 0.34 μM 和 0.039 μM。

生物活性

Tomeglovir is a potent anti-CMVagent, inhibiting processing of viral DNA-concatemers, withIC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV.

IC₅₀& Target

IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)^[1]

体外研究
(In Vitro)

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC₅₀s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC₅₀s of 85 μM and 62.5 μM, respectively^[1]. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC₅₀s of 1.03 ± 0.57 μM and< 1 μM^[2].

体内研究
(In Vivo)

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model^[1]. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD₅₀is >2000 mg/kg in mice and rats^[2].

分子量

441.54

性状

Solid

Formula

C₂₃H₂₇N₃O₄S

CAS 号

233254-24-5

中文名称

托美洛韦

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 108 mg/mL(244.60 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2648 mL	11.3240 mL	22.6480 mL
5 mM	0.4530 mL	2.2648 mL	4.5296 mL
10 mM	0.2265 mL	1.1324 mL	2.2648 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。