Soyasaponin II

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Soyasaponin II

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

55319-36-3

Soyasaponin II 是具有抗病毒活性的皂苷。Soyasaponin II 抑制 HSV-1，HCMV，流感病毒和 HIV-1 的复制。Soyasaponin II 对 HSV-1 复制显示出有效的抑制作用。Soyasaponin II 作为 YB-1 磷酸化和 NLRP3 炎性小体引发的抑制剂，可保护小鼠免受 LPS/GalN 诱导的急性肝衰竭。

生物活性

Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication ofHSV-1, HCMV,influenza virus, andHIV-1. Soyasaponin II shows potent inhibition onHSV-1replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation andNLRP3inflammasomepriming and could protect mice against LPS/GalN induced acute liver failure^[1]^[2].

IC₅₀& Target^[1]^[2]

HSV-1

54 μM (IC₅₀)

HIV-1

112 μM (IC₅₀)

influenza virus

88 μM (IC₅₀)

HCMV

104 μM (IC₅₀)

NLRP3 inflammasome

体外研究
(In Vitro)

Soyasaponin II inhibits the replication of HSV-1 (IC₅₀=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM)^[1].

体内研究
(In Vivo)

Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response^[2].

分子量

913.10

性状

Solid

Formula

C₄₇H₇₆O₁₇

CAS 号

55319-36-3

结构分类

Terpenoids
Triterpenes

来源

Plants
Leguminosae
Glycine sojaSieb. Et Zucc.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)