Oxychloroaphine 可以从天然存在于土壤中的聚块泛亚菌中分离得到。Oxychloroaphine 具有广谱抗真菌活性。Oxychloroaphine 具有浓度依赖性的细胞毒性，导致细胞凋亡 (apoptosis)。Oxychloroaphine 可用于癌症的研究。
| 生物活性 | Oxychloroaphine could be isolated from the bacteriumPantoeaagglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and inducesapoptosis. Oxychloroaphine can be used in research ofcancer[1][2]. |
体外研究
(In Vitro) | Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP[2].
Cell Viability Assay[2] | Cell Line: | A549, HeLa, and SW480 cancer cell lines | | Concentration: | 1, 2, 4, 8, 16, 32, 64, 128, and 256 μM | | Incubation Time: | 24 hours | | Result: | Inhibited cell proliferative in a dose-dependent manner. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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