Niclofolan

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Niclofolan

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

10331-57-4

BAY 9015
Menichlopholan
Menichlofolan
Bilevon

Niclofolan (BAY 9015) 是一种具有口服活性的驱虫剂。Niclofolan 可用于寄生虫感染相关的研究。

生物活性

Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasiteinfection^[1]^[2]^[3].

体外研究
(In Vitro)

Niclofolan (0.12 mg/mL, 60 min) is effective againstGyrodactylussp. underin vitroconditions^[3].

Cell Viability Assay^[3]

Cell Line:	Gyrodactylussp. (parasite)
Concentration:	0.12 mg/mL
Incubation Time:	60 min
Result:	Reduced the number of liveGyrodactylussp. By 100%.

体内研究
(In Vivo)

Niclofolan (2 mg/kg, intramuscular injection) is effective againstfasciola hepaticainfected sheep^[2].
Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects againstP.iloktsuenesisinfected rats^[4].

Animal Model:	fasciola hepaticainfected sheep^[2]
Dosage:	2 mg/kg
Administration:	Intramuscular injection
Result:	Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection.

Animal Model:	Rats infected withP.iloktsuenesis^[4]
Dosage:	1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times.
Administration:	Oral gavage
Result:	Reduced the worms in rats.

分子量

345.09

性状

Solid

Formula

C₁₂H₆Cl₂N₂O₆

CAS 号

10331-57-4

中文名称

硝氯酚；羊肝酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(289.78 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8978 mL	14.4890 mL	28.9779 mL
5 mM	0.5796 mL	2.8978 mL	5.7956 mL
10 mM	0.2898 mL	1.4489 mL	2.8978 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。