| 包装 | 价格(元) |
| 1mg | 询价 |
| 5mg | 询价 |
| Canonical SMILES | FC1=CC=C2C(C(N(C3=CC(Cl)=C(C(C)(C)C)C=C3)C(C4=CC(OCCO5)=C5C=C4)C2CC(O)=O)=O)=C1 |
| 分子式 | C29H27ClFNO5 |
| 分子量 | 524 |
| 溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml,DMSO: 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells. |1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019). |
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