Pamoic acid 是一种有效的 GPR35 激动剂，EC50 为 79 nM。
| Cas No. | 130-85-8 |
| 别名 | 帕莫酸 |
| Canonical SMILES | OC(C1=CC(C=CC=C2)=C2C(CC3=C(C=CC=C4)C4=CC(C(O)=O)=C3O)=C1O)=O |
| 分子式 | C23H16O6 |
| 分子量 | 388.4 |
| 溶解度 | DMSO: 0.2 mg/ml,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pamoic acid is a potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay). It induces GPR35 translocation from the plasma membrane to the cytoplasm with an EC50 value of 22 nM. Pamoic acid also increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a. In vivo, pamoic acid has antinociceptive effects with an ED50 value of 40.5 mg/kg in a mouse abdominal constriction model of visceral pain perception. Pamoate salts, of which pamoic acid is the main constituent, have been used in drug formulations to extend the duration of action. |
