Disitamab vedotin

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Disitamab vedotin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2136633-23-1

RC48

Disitamab vedotin (RC48) 是一种抗体-药物偶联物(ADC)，包含抗人表皮生长因子受体2(HER2)的单克隆抗体，该单克隆抗体通过可降解连接子结合到细胞毒性剂 MMAE。Disitamab vedotin 增强抗肿瘤免疫。

生物活性

Disitamab vedotin (RC48) is an antibody-drug conjugate(ADC)comprising a monoclonal antibody against human epidermal growth factor receptor 2(HER2)conjugated via acleavablelinker to the cytotoxic agent MonomethylauristatinE (MMAE). Disitamab vedotin enhances antitumor immunity^[1].

IC₅₀& Target^[1]

HER2

体外研究
(In Vitro)

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody^[2].

Clinical Trial

性状

Solid

CAS 号

2136633-23-1

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.