Necroptosis-IN-3

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Necroptosis-IN-3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

547698-18-0

Necroptosis-IN-3 (Compound 69) 是一种坏死性凋亡 (necroptosis) 抑制剂，抑制 TNF-α 诱导的坏死性凋亡。Necroptosis-IN-3 (Compound STX1638) 也抑制11β-HSD1。

生物活性

Necroptosis-IN-3 (Compound 69) is anecroptosisinhibitor that inhibits TNF-α inducednecroptosis^[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits11β-HSD1^[2].

IC₅₀& Target

Necroptosis^[1], 11β-HSD1^[2]

体外研究
(In Vitro)

TNF-α-IN-8 (Compound 69) (0.030-100 μM; 24 h) 抑制 TNF-α 诱导的 FADD 缺陷人 Jurkat T 细胞坏死^[1]。

Cell Viability Assay^[1]

Cell Line:	Fadd-/-Jurkat and L929 cells, treated with 10 ng/mL of human TNF-α
Concentration:	0.030-100 μM
Incubation Time:	24 h
Result:	Showed necroptosis inhibitory activity with an ED₅₀of 7.724 μM for Fadd-/-Jurkat cells and was inactive for L929 cells.

分子量

223.33

Formula

C₁₂H₁₇NOS

CAS 号

547698-18-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.