CRT5 是一种吡嗪苯甲酰胺，对经 VEGF 处理的内皮细胞中的所有三种PKD亚型 (对 PKD1、PKD2 和 PKD3 的IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂。CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。
| 生物活性 | CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms ofPKDin endothelial cells treated withVEGF(IC50s = 1, 2, and 1.5 nM forPKD1,PKD2, andPKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
