Pep19-2,5

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Pep19-2,5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1322711-38-5

Pep19-2.5 是一种合成的抗毒素肽，能够阻断细胞内内毒素信号级联。Pep19-2.5 抑制跨膜和胞质模式识别受体 (PRRs) 介导的脂肽 (LP) 和脂多糖 (LPS) 信号通路。该信号级联与炎症和细胞焦亡 (pyroptosis) 有关。

生物活性

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolicpattern recognition receptors(PRRs). The signaling cascades lead to inflammation and cellpyroptosis^[1].

体内研究
(In Vivo)

Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded withCeftriaxone(HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit^[2].

Animal Model:	Sepsis model in male New Zealand rabbits (2-2.5 kg)^[2]
Dosage:	5 mg/kg, combinded with 15 mg/kgCeftriaxone; total volume of 2 mL
Administration:	Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min)
Result:	Killed bacteria and eliminates bacteremia 30 min post challenge; Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge; Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α); And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.

分子量

2712.23

Formula

C₁₃₅H₁₈₇N₃₇O₂₂S

CAS 号

1322711-38-5

Sequence Shortening

GCKKYRRFRWKFKGKFWFWG

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.