生物活性 | GSK2983559 is an orally active and potentreceptor interacting protein 2(RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1]. | ||||||||||||||||
IC50& Target[1] |
| ||||||||||||||||
体外研究 (In Vitro) | GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells[2]. Cell Viability Assay[2]
| ||||||||||||||||
体内研究 (In Vivo) | GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].
| ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 611.61 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H28CaN4O10PS2+ | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 2 mg/mL(3.27 mM;Need ultrasonic) DMSO :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble or slightly soluble) DMF :< 1 mg/mL (ultrasonic;warming;heat to 80℃)(insoluble) Ethanol :< 1 mg/mL (ultrasonic)(insoluble) *GSK2983559 is usually formulated as a suspension. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |