EGFR/HER2/TS-IN-2

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EGFR/HER2/TS-IN-2

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CAS NO:

2444364-04-7

EGFR/HER2/TS-IN-2 (compound 17) 是一种有效的EGFR/HER2和TS抑制剂，其IC₅₀分别为 0.173、0.125 和 1.12 μM。EGFR/HER2/TS-IN-2 对 MDA-MB-231 癌细胞具有细胞毒性活性，其IC₅₀为 1.69 μM。

生物活性

EGFR/HER2/TS-IN-2 (compound 17) is a potentEGFR/HER2andTS(Thymidylate synthase) inhibitor, withIC₅₀values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231cancercell lines, with anIC₅₀of 1.69 μM^[1].

IC₅₀& Target

EGFR

0.173 ± 0. μM (IC₅₀)

HER2

0.125 ± 0. μM (IC₅₀)

体外研究
(In Vitro)

EGFR/HER2/TS-IN-2 (compound 17) shows the GI (growth inhibition)=53.20 and 49.35% towards ovarian cancer IGROV1 and renal cancer UO-31, respectively^[1].

分子量

511.62

Formula

C₂₆H₂₁N₇OS₂

CAS 号

2444364-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.