Plevitrexed (ZD 9331; BGC9331) 是口服有效的胸苷酸合酶 (TS) 抑制剂，Ki值为 0.44 nM。Plevitrexed 通过 α-叶酸受体以及还原的叶酸载体吸收。Plevitrexed 有用于胃癌的潜力。
| 生物活性 | Plevitrexed (ZD 9331; BGC 9331) is an orally active and potentthymidylate synthase(TS)inhibitor with aKiof 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastriccancerin clinical[1][2][3]. |
体外研究
(In Vitro) | ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Kiof~1 μM[3].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
