EGFR/HER2/TS-IN-1

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EGFR/HER2/TS-IN-1

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CAS NO:

2444363-11-3

EGFR/HER2/TS-IN-1 (Compound 4d) 是一种EGFR、HER2和TS (Thymidylate synthase)抑制剂，对 EGFR、HER2 和 TS 的IC₅₀分别为 0.203、0.088 和 0.168 μM。EGFR/HER2/TS-IN-1 诱导 MCF7 细胞凋亡（apoptosis）。

生物活性

EGFR/HER2/TS-IN-1 (Compound 4d) is anEGFR,HER2andTS (Thymidylate synthase)inhibitor withIC₅₀values of 0.203, 0.088 and 0.168 μM againstEGFR, HER2 and TS, respectively. EGFR/HER2/TS-IN-1 induces MCF7 cellapoptosis^[1].

IC₅₀& Target

EGFR

0.203 μM (IC₅₀)

HER2

0.088 μM (IC₅₀)

Thymidylate synthase

0.168 μM (IC₅₀)

体外研究
(In Vitro)

EGFR/HER2/TS-IN-1 (Compound 4d) shows cytotoxicity with an IC₅₀of 0.693 μM against MCF7 cells^[1].
EGFR/HER2/TS-IN-1 (10 μg, 24 h) arrests cell cycle at G2/M phase and induces cell apoptosis in MCF7 cells^[1].

Cell Cycle Analysis^[1]

Cell Line:	MCF7
Concentration:	10 μg
Incubation Time:	24 h
Result:	Arrested cell cycle at G2/M phase.

Apoptosis Analysis^[1]

Cell Line:	MCF7
Concentration:	10 μg
Incubation Time:	24 h
Result:	Induced cell apoptosis.

分子量

501.54

Formula

C₂₄H₁₅N₅O₄S₂

CAS 号

2444363-11-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.