Levoleucovorin Calcium

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CAS NO:

80433-71-2

左亚叶酸钙
Calcium Levofolinate
CL307782

Levoleucovorin Calcium (Calcium levofolinate) 是 Leucovorin Calcium (HY-13664) 的左旋异构体，具有抗肿瘤作用。Levoleucovorin Calcium 也是5-Fluorouracil (HY-90006) 抗癌细胞毒性的增强剂。

生物活性

Levoleucovorin Calcium (Calcium levofolinate), a levo isoform ofLeucovorin Calcium(HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of5-fluorouracil(HY-90006) cytotoxicity againstcancer^[1]^[2].

体内研究
(In Vivo)

Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of5-Fluorouracil^[2].

Animal Model:	Crj:CD(SD)BR rats (5 weeks)^[2]
Dosage:	6, 20 or 60 mg/kg/day
Administration:	i.v.; for 4 weeks (combined with 10 mg/kg/day5-Fluorouracil)
Result:	Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs. Induced the potentiation in the toxicity of5-Fluorouracilappeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.

Clinical Trial

分子量

511.50

性状

Solid

Formula

C₂₀H₂₁CaN₇O₇

CAS 号

80433-71-2

中文名称

叶酸杂质15

结构分类

Ketones, Aldehydes, Acids

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 10 mg/mL(19.55 mM;Need ultrasonic)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.9550 mL	9.7752 mL	19.5503 mL
5 mM	0.3910 mL	1.9550 mL	3.9101 mL
10 mM	0.1955 mL	0.9775 mL	1.9550 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。