L-651,582 (L-651582) 是一种非电压操作的钙通道和钙通道介导的信号通路的细胞抑制抑制剂。
| Cas No. | 99519-84-3 |
| 别名 | 5-氨基-1-(3,5-二氯-4-(4-氯苯甲酰基)苄基)-1H-1,2,3-三氮唑-4-甲酰胺,L-651582; CAI |
| 化学名 | 5-amino-1-(3,5-dichloro-4-(4-chlorobenzoyl)benzyl)-1H-1,2,3-triazole-4-carboxamide |
| Canonical SMILES | ClC1=CC(CN2N=NC(C(N)=O)=C2N)=CC(Cl)=C1C(C(C=C3)=CC=C3Cl)=O |
| 分子式 | C17H12Cl3N5O2 |
| 分子量 | 424.67 |
| 溶解度 | <42.47mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carboxyamidotriazole (L 651582) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2]. References:
[1]. Chen C, et al. Carboxyamidotriazole Synergizes with Bay 43-9006 to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229.
[2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63. |
