WS 12 (AR-15512) 是一种有效的选择性 TRPM8 激动剂，薄荷醇衍生物，用作清凉剂。 WS 12 具有镇痛作用，可用于慢性神经性疼痛研究。
| Cas No. | 68489-09-8 |
| 别名 | 凉味剂WS-12,AR-15512; AVX-012 |
| 化学名 | (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide |
| Canonical SMILES | O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC(C=C2)=CC=C2OC |
| 分子式 | C18H27NO2 |
| 分子量 | 289.41 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | WS-12 is an agonist of TRPM8 with an EC50 of 39 nM. References:
[1]. Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41(3):285-94. |
