PD 118057 是一种 hERG 通道激活剂，不会导致 hERG 阻断。
| Cas No. | 313674-97-4 |
| 化学名 | 2-((4-(3,4-dichlorophenethyl)phenyl)amino)benzoic acid |
| Canonical SMILES | ClC1=CC(CCC(C=C2)=CC=C2NC3=CC=CC=C3C(O)=O)=CC=C1Cl |
| 分子式 | C21H17Cl2NO2 |
| 分子量 | 386.27 |
| 溶解度 | <38.63mg/ml in DMSO;<7.73mg/ml in ethanol |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade[1]. References:
[1]. Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481. |
