187-1,N-WASP inhibitor TFA

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187-1, N-WASP inhibitor TFA 是一种14-aa 环肽，也是一种变构神经 Wiskott Aldrich 综合征蛋白 (N-WASP) 抑制剂。187-1, N-WASP inhibitor TFA 有效抑制由磷脂酰肌醇 4,5-二磷酸酯 (PIP2) 诱导的肌动蛋白装配，IC₅₀为 2 μM。187-1, N-WASP inhibitor TFA 通过稳定蛋白质的自抑制状态，阻止了N-WASP激活Arp2/3。

生物活性	187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allostericneural Wiskott-Aldrich syndrome protein (N-WASP)inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with anIC₅₀of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation ofArp2/3complex by N-WASP by stabilizing the autoinhibited state of the protein^[1]^[2].
分子量	1898.13
Formula	C₉₈H₁₂₃F₃N₁₈O₁₈
Sequence	Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}]
Sequence Shortening	Cyclo[QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}-QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}]
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.