Meclofenamic acid

立即咨询

Meclofenamic acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

644-62-2

Meclofenamate

Meclofenamic acid (Meclofenamate) 是一种非甾体抗炎剂。Meclofenamic acid 是一种高选择性的脂肪和肥胖相关酶 (FTO) 抑制剂。Meclofenamic acid 与 FTO 竞争，与含有 m(6)A 的核酸结合。Meclofenamic acid 是一种非选择性的缝隙连接 (gap-junction) 阻滞剂。Meclofenamic acid 抑制hKv2.1和hKv1.1，其IC₅₀分别为 56.0 和 155.9 μM。

生物活性

Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selectiveFTO(fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selectivegap-junctionblocker. Meclofenamic acid inhibitshKv2.1andhKv1.1, withIC₅₀values of 56.0 and 155.9 μM, respectively^[1]^[2]^[3]^[4].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Meclofenamic acid (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner^[1].
Meclofenamic acid inhibits enzyme cyclooxygenase, with an IC₅₀about 1 μM, thereby inhibiting the production of prostaglandins^[2].
Meclofenamic acid inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins^[2].

Western Blot Analysis^[1]

Cell Line:	HeLa cells
Concentration:	0, 12.5, 25, 50, 100 μM
Incubation Time:	24 h
Result:	Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.

Clinical Trial

分子量

296.15

Formula

C₁₄H₁₁Cl₂NO₂

CAS 号

644-62-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.