ARQ 621

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ARQ 621

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CAS NO:

1095253-39-6

ARQ 621 是一种变构的有效的选择性Eg5抑制剂，Eg5 是一种参与细胞分裂的基于微管的 ATPase 运动蛋白。ARQ 621 具有抗肿瘤活性。ARQ 621 是一种驱动蛋白 (kinesin) 抑制剂。

生物活性

ARQ 621 is an allosteric, potent and selective inhibitor ofEg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity^[1]. ARQ 621 is akinesininhibitor^[2].

IC₅₀& Target^[1]

Eg5

体外研究
(In Vitro)

Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target^[1].

Clinical Trial

分子量

552.43

性状

Solid

Formula

C₂₈H₂₄Cl₂FN₅O₂

CAS 号

1095253-39-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)