BOS-172722

立即咨询

BOS-172722

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1578245-44-9

BOS-172722 是单极纺锤体 1(MPS1)检查点的抑制剂，其对MPS1 (1 mM ATP) 和P-MPS1 的IC₅₀值分别为 11 nM 和 63 nM。BOS-172722 可用于多种乳腺癌的研究。

生物活性

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC₅₀of 11 nM and 63 nM forMPS1(1 mM ATP) and P-MPS1, respectively. BOS-172722 also has potential for the study of various forms of breastcancer^[1].

IC₅₀& Target

2 nM (MPS1)^[1].

体外研究
(In Vitro)

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC₅₀of 2 nM. BOS-172722 also has potential for the treatment of various forms of breast cancer^[1].

体内研究
(In Vivo)

BOS-172722 shows excellent PK in mouse, rat, and dog^[1].
BOS-172722 (50 mg/kg) results in an increased suppression of MPS1 autophosphorylation at 6 and 24 h^[1].

Animal Model:	Dog^[2].
Dosage:	1 mg/kg (iv), 5 mg/kg (po) (Pharmacokinetic Analysis).
Administration:	IV and PO.
Result:	T1/2 = 12 h, Cmax_po= 7770 nmol/L, AUC_po= 147035 h*nmol/L.

Clinical Trial

分子量

446.55

性状

Solid

Formula

C₂₄H₃₀N₈O

CAS 号

1578245-44-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

1M HCl : 65 mg/mL(145.56 mM;ultrasonic and adjust pH to 2 with HCl)

DMSO : 5 mg/mL(11.20 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2394 mL	11.1970 mL	22.3939 mL
5 mM	0.4479 mL	2.2394 mL	4.4788 mL
10 mM	0.2239 mL	1.1197 mL	2.2394 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。