MPH-220

立即咨询

MPH-220

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2649776-79-2

MPH-220 是一种选择性的、具有口服活性的骨骼肌myosin-2抑制剂。MPH-220 可使肌肉放松。MPH-220 是一种抗痉挛剂，可用于痉挛和肌肉僵硬的研究。

生物活性

MPH-220 is a selective and orally active inhibitor of skeletal musclemyosin-2. MPH-220 enables muscle relaxation. MPH-220 is anti-spastic agent that can be used in the research of spasticity and muscle stiffness^[1].

体外研究
(In Vitro)

MPH-220 (0-50 μM) 抑制人肌肉肌球蛋白样品中肌动蛋白激活的 ATP 酶活性^[1]。

体内研究
(In Vivo)

MPH-220 (25-30 mg/kg，腹腔注射或口服灌胃) 可降低麻醉大鼠的骨骼肌力量，而不会影响心血管^[1]。
MPH-220 (15 mg/kg，口服) 改善脑损伤大鼠的步态功能^[1]。

Animal Model:	Anesthetized rats^[1]
Dosage:	25-30 mg/kg
Administration:	Intraperitoneal injection (i.p.) or oral gavage
Result:	Reduced skeletal muscle force. Observed MPH-220 distribution in rat tissues in a time-dependent manner and a dose-dependent, few-fold accumulation in skeletal muscle.

分子量

383.46

Formula

C₂₀H₂₁N₃O₃S

CAS 号

2649776-79-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.