NVS-PAK1-C

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NVS-PAK1-C

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2250019-95-3

NVS-PAK1-C 是一种有效的、ATP 竞争的特异性变构PAK1抑制剂探针，对于去磷酸化的 PAK1 和磷酸化的 PAK1，IC₅₀值分别为 5 nM 和 6 nM。NVS-PAK1-C 也可以抑制去磷酸化的 PAK2 (IC₅₀=270 nM) 和磷酸化的 PAK2 (IC₅₀=720 nM)。

生物活性

NVS-PAK1-C is a potent, ATP-competitive and specific allostericPAK1inhibitor probe withIC₅₀values of 5 nM and 6 nM for dephosphorylatedPAK1and phosphorylatedPAK1, respectively. NVS-PAK1-C is also against dephosphorylatedPAK2(IC₅₀=270 nM) and phosphorylatedPAK2(IC₅₀=720 nM)^[1].

IC₅₀& Target

PAK1

0.007 μM (Kd)

PAK2

0.4 μM (Kd)

PAK1

5 nM (IC₅₀)

PAK2

270 nM (IC₅₀)

体外研究
(In Vitro)

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 μM in the Su86.86 cell line and MEK S289 phosphorylation with an IC₅₀=0.21 μM in Su86.86 cells in which PAK2 is downregulated^[1].

分子量

465.90

Formula

C₂₂H₂₃ClF₃N₅O

CAS 号

2250019-95-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.