PAK1-IN-1

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PAK1-IN-1

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CAS NO:

2485732-30-5

PAK1-IN-1 是一种有效的选择性PAK1抑制剂，IC₅₀为 9.8 nM。PAK1-IN-1以剂量依赖性方式抑制 PAK1 相关肿瘤细胞的迁移和侵袭。

生物活性

PAK1-IN-1 is a potent and selectivePAK1inhibitor with anIC₅₀of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner^[1].

IC₅₀& Target^[1]

PAK1

9.8 nM (IC₅₀)

PAK4

>10 μM (IC₅₀)

体外研究
(In Vitro)

PAK1-IN-1 (compound 30l) (0-10 μM) shows selectivity with IC₅₀s of 0.01, >10 μM for PAK1 and PAK4, respectively^[1].

Cell Proliferation Assay^[1]

Cell Line:	MDA-MB-231, HCT-116 cells
Concentration:	1 μM
Incubation Time:	72 h
Result:	Showed antiproliferative activity against MDA-MB-231and HCT-116 cells with inhibition of 6.31% and 8.73%, respectively.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	2.5, 5, 10, 20 μM
Incubation Time:	1, 24 h
Result:	Decreased the expression of activated PAK1 (PAKp-Ser144) and Snail in a dose-dependent manner.

分子量

469.92

Formula

C₂₆H₂₀ClN₅O₂

CAS 号

2485732-30-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.